How Should Advanced Synovial Sarcoma Patients Do If Inapplicable to Surgery, Chemotherapy and Radiotherapy?

Synovial sarcoma is a malignant tumor which derives from joints, synovium and tendon sheath of synovial tissue. It can be mainly removed by surgery. The major clinical symptoms are local swelling, lumps, pain and activity limitation. For middle and advanced stage patient, oftentimes there are already with multiple metastases. When it occurs, surgical removal would lose its practical meaning. What should the patient do? The ward Director Ma Xiaoying in St. Stamford Modern Cancer Hospital Guangzhou recommended that the tumor can be controlled through effective minimally invasive treatment. In addition, the lifetime can be prolonged and life quality improved.

Vera is a middle and advanced stage synovial sarcoma patient from Canada. Though she got the tumor removed by surgery at local hospital, little therapeutic effect caused repeatedly recurrence, which made the condition being out of control by local doctors. It was her responsibility as a mother and desire of survival that prevented her from giving up. Instead, she chose to undergo minimally invasive treatment, which brought her back to life in St. Stamford Modern Cancer Hospital Guangzhou.

Tumor is like chive, an endless process of being removed and growing back.

She is 70 years old now and there’s a soybean-liked lump occurred on her left neck when she was 40. She didn’t pay attention to it due to being engaged in work and her family. 12 years later, the lump enlarged and she was diagnosed as left neck synovial sarcoma stage II. According to the local doctors’ advice, she underwent surgery. Removal of early malignant tumor often goes with chemotherapy and radiotherapy, which jointly avoids recurrence and metastasis. However, chemotherapy and radiotherapy do severe harm to human body with its side effects of nausea and vomiting.

Synovial Sarcoma, interventional therapy, particle implantation, microwave ablation, St. Stamford Modern Cancer Hospital Guangzhou


Vera refused to undergo chemotherapy and radiotherapy, while she suffered from 4 recurrences and 3 surgical removals in later 18 years. Until the 4th surgery, as big as a cabbage, the tumor broke and bled. She even fainted once due to hypotension caused by excessive loss of blood. “I passed out and hit the ground; my forehead broke and received 12 stitches. However, when I woke up, finding out there was blood all over the floor and it looked like a crime scene”, according to her description. Doctors had no choice but to say “sorry, there’s no other treatment left.”

Vera has 4 children. Her husband unfortunately died of colon cancer in her 50. Facing the cruel reality, she had no choice but to figure out the solution to deal the plight ahead, rather than immerse in sorrow. Afterwards, she got to know St. Stamford Modern Cancer Hospital Guangzhou online and the consultant told her: “we provide 18 methods of minimally invasive treatment for cancer.”

When arriving at St. Stamford Modern Cancer Hospital Guangzhou, Vera was in rather weak condition. On one hand, the tumor had increase to 12cm*10cm, accompanying with bleeding. On the other hand, she also had severe symptoms of low protein, anemia and stagger. Multidisplinary Team(MDT) from MGHG immediately held a meeting based on Vera’s case. Back then she has progressed to middle and advanced stage with lymph node metastasis. There was no operation indication, being insensitive to chemotherapy and radiotherapy. Moreover, rupture hemorrhage would occur at any time, which was life-threatening. To control the symptom of hemorrhage, Multidisplinary Team(MDT) resolutely decided to apply interventional embolization to Vera.

Synovial Sarcoma, interventional therapy, particle implantation, microwave ablation, St. Stamford Modern Cancer Hospital Guangzhou


Interventional therapy is a minimally invasive therapy performed under the guidance of medical imaging equipment. Put a special tube into the body through which injects strong anticancer drugs into the tumor location and cut off the tumor’s blood supply and cause cancer cells to death. It is known that embolism with anticancer drugs has sustained release effect on the tumor, which is paramount in cancer treatment. The treatment also went with microwave ablation. Except for a little hot during microwave ablation, she didn’t suffer any discomfort from other treatments, she said.

According to Director Ma Xiaoying, after interventional therapy, hemorrhage had been under controlled, and the tumor greatly shrunk. Index of hemoglobin and protein also backed to normal. Currently, Vera takes care of herself and lives as a normal person. The most important part is that she could honor her responsibility as a mother again.

Sarcoma, a rare malignant tumor, represents about three percent of one hundred thousand all over the world. Incidence rate of synovial sarcoma is even less, only accounting 10% in soft tissue sarcoma. Due to less obviousearly symptoms, synovial sarcoma is often misdiagnosed as injury or arthritis with symptoms such as arthralgia and joint swelling, especially for young people featuring high incidence rate. Mostly, the symptoms were mistaken as recent injury from exercise or ostealgia during anagen. Not until severe pain occured due to disease progression, they will not seek medical advice and at that time, it always indicates middle or advanced stage. Therefore, Director Ma also recommended that once abnormal lump detected in organs such as joints, legs and neck, one should undergo screening and diagnosis in professional medical institution. Once being diagnosed, timely treatment in experienced medical center should be taken. “Early radical surgery can reduce the tumor recurrence rate, while middle and advanced stage patients should consider comprehensive treatments such as minimally invasive treatment, targeted therapy and chemotherapy or radiotherapy.” said Ma.

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